It’s possible to overdose on hydrocodone. Never take more than your prescribed dose of hydrocodone, even if you feel that the medicine is not working as well. Be sure to also tell your doctor if you’re taking any other prescription or nonprescription medications. You shouldn’t drink alcohol or take other street drugs while taking hydrocodone as these will increase your risk of experiencing serious side effects. There are also a number of factors that could alter the time it takes for hydrocodone to clear the body, including age, metabolism, weight, dose, and other medications. But the drug may still be detected in the saliva for up to 36 hours, in urine for four days, and in the hair for 90 days after the last dose. The pain relief effect of hydrocodone will wear off within four to six hours.
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